Should we consider Progesterone Cream for Endometriosis?

Should we consider Progesterone Cream for Endometriosis?

I have been researching this one for a while now and will be bringing out a series of articles on the topic because it is really quite an in depth one!

One of the key reasons we want to use Progesterone cream is to really just give ourselves a chance to heal from existing Endometriosis. It can often feel like an uphill battle trying to beat this thing! We are constantly forming new cells in the wrong places and with excess Estrogens being a common symptom of Endometriosis, these cells are simply encouraged to grow more.


Let me explain this one a little more. Essentially, Oestrogens and Progesterones oppose each other in our bodies. They need to work on a jing jang effect – neither should be higher than the other and each one should level each other out. If we are lacking in Progesterone, our oestrogen will go up. If we are lacking in oestrogen, our progesterone will go up.  We don’t want either to be too high or too low. They need to both exist in perfect balance with eachother. Many women with Endometriosis suffer from Oestrogen Dominance – in other words they don’t have enough progesterone to balance out the estrogen and therefore have too much estrogen. Estrogen creates growth. That is it’s main function. It will draw with it a series of symptoms which are all in line with wanting to create growth, many of which we are familiar with.


Here is a comprehensive list of symptoms you may experience with estrogen dominance:

  • Acceleration of aging
  • Increased body fat and weight gain
  • Salt and fluid retention
  • Breast tenderness
  • Foggy thinking
  • Depression, anxiety and headaches
  • Cyclical migraines
  • Impairs blood sugar levels
  • Impairs the thyroid function – particularly hypothyroidism
  • Little or low libido
  • Increase risk of blood clots and growth
  • Cell proliferation in “womanly bits” – breast growths, fibroids, endometrial cells, cancers
  • Dilates blood vessels
  • Triggers autoimmune diseases and responses – like allergies and skin sensitivities
  • Bladder infections and bladder issues – possibly even Interstitial Cystitis
  • Loss of zinc and retention of copper
  • Increase risk of gallbladder disease
  • Miscarriages
  • PMS



It is likely that you don’t have all of these symptoms or even to the extent of them. We are all different and it is important to test your hormone levels before using any specific progesterone cream for levelling out your hormones – mainly so you know where you are at and can measure if they are working for you. There are a number of other imbalances in the body which can actually illustrate very similar symptoms and you may be “barking up the wrong tree”. Hypothyroidism often displays many similar symptoms to estrogen dominance and the approach would be quite different in treating that one.

However, there is also no inherent danger in using progesterone cream – according to Dr John Lee. He expresses that the only way progesterone creams can be harmful is if they are not real progesterone and if too high a dosage is used. You can read his book to gain a full comprehensive understanding of progesterone cream.I have been researching this one for a while now and will be brining out a series of articles on the topic because it is really quite an in depth one!

Real progesterone will actually be listed as an ingredient in the cream – it is not wild yam or progestin. Progestin is a pharmaceutically created product and your body will not be able to synthesise this correctly or expel it correctly. It needs to actually list progesterone as an ingredient.

How to use Progesterone Cream

Progesterone will stay in your body for up to 12hrs. The levels will be at their highest at 3/4hrs after use. It is best to take progesterone in the morning and at night.
• Use no more than 20mg per day – just measure your body and see how it feels. If you start to get any adverse symptoms, simply lower the dose. It is okay to experiment and work out what your body needs – according to Dr John Lee.
• Rotate where you apply it – don’t put it on the same place every day.
• Put it on the thin areas of skin – the face, neck, chest, inside arm
• Spread it wide! Spread over a larger area of skin to get the best absorption
• Apply after showering or bathing

My personal opinion on Progesterone Cream and how they fit in with healing endo

I think progesterone creams can certainly help us feel better. They will lower the proliferation of cells forming and growing in the wrong places! What they can do is give us a chance to rectify the problem – the cells are at their smallest and we can then flush them out and reduce the inflammatory response in the area by flushing out more toxins.
I personally don’t believe it is a long term fix for endo. – Just my opinion. I think endo is not just about regulating hormones and cell growth. The endo got there due to a different imbalance and progesterone cream doesn’t get to the source of that imbalance.

I would personally only recommend taking progesterone cream for about 4months and see if it has helped. Use that time to focus on healing the rest of your body – like your liver and your colon etc.

I am going to be doing heaps more research on the subject so you never know I might feel differently about it in a few months but for now…. These are my thoughts. If you have used progesterone cream please feel free to share. – positive or negative. It is worth sharing so others can learn more.

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Big hugs and healing,

19 Responses to Should we consider Progesterone Cream for Endometriosis?

  1. Dear Melissa,I have endometriosis and all the symptoms of estrogen dominance (water retention,fatigue, migraine….) I bought progesterall cream and started by a small dose but I am suffering a lot: mood swings I cry then I laugh ,excess fatigue even worse than before . Very intense foggy thinking even dyslexia. i stoped it today. What is going wrong? Please help

    • Hi Tony,
      It could be that your body is converting the progesterone back to oestrogen. I would recommend focusing on liver health, rather than simply looking at hormone imbalances. Did you have your hormone levels tested before trying this?

  2. Melissa,

    Progesterone cream really works for endometriosis. It’s not a miracle cure because you have also to work on the real causes of endometriosis… lifestyle and emotions… But progesterone cream help to counterbalance estrogens that are a growing factor for endometriosis tissue. During this time, it’s easier for the body to heal itself and to repair tissues.

    BUT…. it’s very important to use progesterone cream the right way. I use progesterone as it is recommended by Dr Lee FOR ENDOMETRIOSIS.

    60-70 mg per day (not 20-25 mg per day)

    It is very important to have a good dose when you start…. if not, it will worsen endometriosis… as you know that progesterone make estrogens working better.

    And you have to buy a cream that contains real progesterone USP… and not phytoestrogens…..

    I took this cream during a few years and it helps me a lot to balance my body!
    But as you know, it’s not the only thing I done…

  3. I read about this cream, but I find out that it’s quite difficult to find a reliable version in Brazil. I mean, one that doesn’t use vaseline. It seems interesting, though. I’m not very sure yet. I want to ask if you heard about agnus castus? I took a solution of this plant for 6 months and it helped a lot! My periods got less painful and they are shorter, as well.

    • Hi Tais,
      I shall do some follow up articles on where to get a good quality brand. I have heard of agnus cactus and I think it can be beneficial for a short time. Glad it is working for you :)

  4. my gp won’t test my hormones. says as i have conceived i am obviously ovulating so my hormones must be fine. i am convinced, 4 miscarriages later that i have a hormone imbalance. can you get testing independently somehow?

  5. Hi lovely,

    I am going to have my hormones tested and if appropriate try the cream. Will let you know how it goes!

    If you’re researching – Dr Christiane Northrup has some very interesting info on the cream.

    Also, I’m going to pop some yogic breath work for endo on youtube soon. This is great for those who feel yoga can be a little too strenuous and for those who want to work with breath ( very effective). Yoga can actually rebalance your hormonal system all on it own!


  6. My doctor started me on compounded progesterone 25 mg. Dropped it to 10 mg and I noticed no change after months. In fact I really felt sick every morning after taking at night. I have now since been off for a few weeks and he has tried me on ovnet ( have you ever heard of it) Google it. Anyway there is a percentage of women that can not tolerate the progesterone. I was taking it to lower my estrogen because I was so dominant. I have not noticed much of a difference, but I have not been waking up sick :).
    I tried the cream years ago and had no change also. I am also taking armour for hypo throid for 2 months and have not noticed any real difference.
    Time will tell.
    I really think it is all about listening to the body.

  7. I have tried natural progesterone cream and I was really hoping it would help with my sore breasts in the luteal phase, but no dice.
    On a monitored cycle I did have very high progesterone peak+7 (50!), so it was definitely working.

    • Interesting :) I have also heard that sore breasts can be water retention. Maybe add some lemon to your daily water and see what happens this months cycle.

  8. Thanks for posting this article! I’m going on my third month with progesterone cream, and I love it. I had a lap in November, so hopefully this will help with the endo growth and FERTILITY! Anxious to hear others’ experiences with the cream.

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